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br around the CD stained neo vasculatures Compared
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around the CD31-stained neo-vasculatures. Compared with control, the deficiency in catecholamines caused a significant reduction in MVD and M2 density in lung cancer models. After 6OHDA treatment, the MVD dropped to less than half of those in control groups in both the H446 and HCC827 models wi
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br Results br Qualitative assessment br The aerial parts
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3. Results 3.1. Qualitative assessment The aerial parts of the four C. curetum solvent fractions contained a wide range of secondary metabolites, as shown in Table 1. The results show that the aqueous fraction was rich in secondary and primary metabolites including flavonoids, tannins, pheno
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Cancer Letters br Cells and culture conditions br Human
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Cancer Letters 444 (2019) 70–81 2.3. Cells and culture conditions Human pancreatic stellate cell (PSC) lines were established from fresh surgical specimens of pancreatic cancer using the outgrowth method [21–23]. Pancreatic cancer cell (PCC) lines from the primary tumors of KPC mice were al
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br Time months br survival br Overall br Patients at
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Time (months) survival Overall Patients at Risk Time (months) C free survival 0.75 -Progression Patients at Risk Time (months) survival Overall Patients at Risk Time (months) Abbreviations: ALDH ¼ aldehyde dehydrogenase; EGFR ¼ epidermal growth factor rec
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br to examine angiogenesis in brain
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to examine angiogenesis in beta-Nicotinamide mononucleotide tumours. As shown in Fig. 5J-K, tu-mours treated with BCF showed significant decrease in micro-vessel density, demonstrating that BCF decreases miR-1246 levels in exosomes to inhibit angiogenesis in brain microenvironment. In addition to
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ref br cMET cellular Mesenchymal Epithelial Transition facto
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ref. cMET: cellular Mesenchymal Epithelial Transition factor, ALK: Anaplastic Lymphoma Kinase, LCLC: Large-Cell Lung Cancer, NOS: Not Otherwise Specified, HR: Hazard Ratio, Ref: Reference, CI: Confidence Interval. 4. Discussion The role of c-MET protein overexpression as a prognostic and
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br BCRP overexpression attenuates HY accumulation in
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3.2. BCRP overexpression attenuates HY accumulation in cBCRP cells To define the extent of the impact of particular ABC transporter overexpression on intracellular HY content, we measured the kinetics of HY incorporation into the Butyrolactone I by flow cytometry. Analyses of HY content were p
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systems br Khosravia et al Deep convolutional
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systems Khosravia et al. [11] 2018 Deep convolutional neural Classifying the various Increase the precision of Computation cost was not networks (CNN) cancer tissues diagnosis and minimizes minimized the error Sharma et al. [18] 2018 Two-stage hybrid ensemble Classifying the c
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br Holmqvist AS Olsen JH
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[10] Holmqvist AS, Olsen JH, Andersen KK, de Fine Licht S, Hjorth L, Garwicz S, et al. Adult life after childhood cancer in Scandinavia: T16AinhA01 following treatment for cancer in childhood. Eur J Canc 2014;50(6):1169e75. [11] Wilson CC, Liu W, Yang JJ, Kang G, Ojha RP, Neale GA, et al. Gene
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br Schulman S Kearon C Definition of major
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15. Schulman S, Kearon C. Definition of major bleeding in clinical investi-gations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 2005;3:692–694. 17. Sherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE,
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br In the present study di erent ratios of PSCs
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In the present study, different ratios of PSCs could mimic the dif-ferent stages of PDAC spheroids. Some literature has shown that the prominent stromal reaction of increased alpha-smooth muscle NS638 (α-SMA) expression can lead to the worse outcomes on pancreatic cancer patients [48,49]. The lite
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br Cell viability assay br Cells were
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2.8. Cell viability assay Cells were seeded in 96-well plates at a density of 3000 cells/well in DMEM media. On the next day, the media were aspirated, 4-hydroxy Nonenal were washed with PBS, and serine-replete or -deplete media containing compound (0, 50 μM) or DMEM media containing compound
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br Our study is retrospective and
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Our study is retrospective and had a relatively small number of patients, which indicates that the results must be interpreted care-fully. In concordance with 2 previously published studies by Choy et al15 and Park et al,31 our results indicate that the intraoperative Lymph Node Tattooing and T
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br TP INP overexpression resulted in
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TP53INP2 overexpression resulted in a trend toward increased cancer-induced muscle loss also in female mice, at both early and late stages of cachexia (Fig. S3). To understand the molecular alterations associat-ed with muscle wasting in WT and Tg TB mice, the PD-98059 of relevant genes was ass
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br Autophagy is involved in a variety of cellular mechanisms
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Autophagy is involved in a variety of cellular mechanisms, each of which in-hibits tumor progression by activating multiple molecular pathways. Levine, 2008; Liu and Levine, 2015). The high level of genetic in-stability in cancer U73122 allows accumulation of spontaneous mutations and epigeneti